金宁一 中国工程院院士 职 称： 研究员   深圳市三名工程团队：军事医学科学院金宁一院士人兽共患病毒性疾病诊治研究团队 电 话： +86-755-25533018 传 真： +86-755-25504575 Email： ningyik@126.com 个人简历 学术成果简介

1982年毕业于延边农学院，军事医学科学院技术一级研究员、博士生导师，2015年入选为中国工程院院士。现任军事医学科学院十一所分子病毒学与免疫学实验室主任、全军基因工程重点实验室主任、吉林省病毒重组疫苗研发工程中心主任、吉林省人兽共患病防控科技创新中心主任；国务院学位委员会第五届学科评议组成员，国家第十一届药典委员会执行委员，全国动物防疫专家委员会委员，农业部第五届农业转基因生物安全委员会委员，中国畜牧兽医学会顾问委员会委员、动物传染病学分会理事长，中国微生物学会病毒学专业委员会副主任委员，全军第6、7、8、9届医学科学委员会委员，吉林省科协副主席、免疫学会副理事长、生物治疗学会副理事长等；《病毒学报》、《中国兽医学报》、《军事医学》等多种期刊杂志副主编或编委。

40余年来，金宁一研究员一直坚守在科研和防控工作第一线，紧紧围绕病原学、流行病学、快速诊断、预防和治疗用疫苗等病毒病防控理论和关键技术进行系统研究和集中攻关，不仅在基础研究领域取得了创新性研究成果，而且在人才培养、学科建设、应用开发以及人兽共患病毒性疾病综合防控等方面均取得了卓越成绩。其带领团队长期从事病毒学研究，对12种重要的人兽共患病毒（禽流感病毒、乙型脑炎病毒、戊型肝炎病毒、SARS冠状病毒、甲型H1N1流感病毒等）进行了系统研究，其牵头完成的“重要病毒病防控关键技术研究与应用”项目于2012年申报并获得1项国家科技进步一等奖，所取得的研究成果和创建的科技平台，推动了行业进步，为有效提升我国病毒病综合防控水平提供了理论和技术支撑，具有重大科学与社会意义。

1998年获本行业第一个国家杰出青年科学基金，2000年享受政府特殊津贴，2005年获全国优秀科技工作者称号。获军队杰出专业技术人才奖、全军优秀教员、“何梁何利”科学与技术进步奖。先后主持省部级以上课题67项；获省部级二等奖以上科技成果17项，作为第一完成人获国家科技进步一等奖1项、省部级科技进步一等奖4项、二等奖5项；授权国家发明专利12项；成果转让2项；获新型疫苗转基因生物安全证书6项；以通讯作者在Nature Communication、Science Signaling、Cell Research、Journal of Virology等国内外期刊发表论文629篇；主编专著2部；已为国家培养研究生267名。

教育经历

1978-03-01至1982-01-31    延边农学院，兽医，大学本科

1982-09-01至1985-08-31    中国人民解放军兽医大学，兽医微生物，硕士

1992-08-01至1995-05-31    中国人民解放军农牧大学，预防兽医学，博士

工作经历

1982-08-01至1987-08-31    延边农学院、解放军兽医大学，助教/研究实习员

1987-09-01至1992-11-31    解放军兽医大学（农牧大学），助理研究员

1990-09-01至1993-07-31    日本京都大学病毒研究所，共同研究员/在留资格教授

1993-12-01至1994-11-31    韩国汉城大学遗传工学研究所，共同研究员

1994年        晋升为解放军农牧大学（军需大学、军事医学科学院）研究员

1994年        任中国人民解放军基因工程重点实验室主任

2007年        任吉林省人兽共患病防控科技创新中心主任

2011年        任吉林省病毒重组疫苗研发工程研究中心主任

2015年至今    中国工程院院士

作为项目负责人主持的国家级及省部级课题：

1. 2016-01-01至2018-12-31，国家重点研发计划项目：重要新发突发病原体防治、处置技术与产品研究

2. 2012-01-01至2014-12-31，973前期计划项目，农业生物安全与关键技术研究

3. 2014-01-01至2016-12-31，国际合作项目，流感跨种通用重组腺病毒疫苗关键技术合作研究

4. 2015-01-01至2017-12-31，吉林省重大科技攻关，抗肿瘤创新药物制备工艺、药理学和毒理学研究

代表性著作及论文（均为通讯或共同通讯）

1. YAN YI-WU, Zou Zhen, SUN YANG, LI XIAO, SU KAI-FENG, WEI YU-QUAN, JIN NING-YI, JIANG CHENG-YU. Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model. Cell research. 2013, 23(2): 300-302.

2. ZOU ZHEN, YAN YI-WU, SHU YUE-LONG, GAO RONG-BAO, SUN YANG, LI XIAO, JU XIANG-WU, LIANG ZHU, LIU QIANG, ZHAO YAN, GUO FENG, BAI TIAN, HAN ZONG-SHENG, ZHU JIN-DONG, ZHOU HUAN-DI, HUANG FENG-MING, LI CHANG, LU HUI-JUN, LI NING, LI DANG-SHENG, JIN NING-YI, PENNINGER JOSEF-M, JIANG CHENG-YU. Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections. Nature communications. 2014, 5:3594.

3. SUN YANG, LI CHENG-GANG, SHU YUE-LONG, JU XIANG-WU, ZOU ZHEN, WANG HONG-LIANG, RAO SHUAN, GUO FENG, LIU HAO-LIN, NAN WEN-LONG, ZHAO YAN, YAN YI-WU, TANG JUN, ZHAO CHEN, YANG PENG, LIU KANGTAI, WANG SHUNXIN, LU HUI-JUN, LI XIAO, TAN LEI, GAO RONG-BAO, SONG JING-DONG, GAO XIANG, TIAN XINLUN, QIN YING-ZHI, XU KAI-FENG, LI DANG-SHENG, JIN NING-YI, JIANG CHENG-YU. Inhibition of autophagy ameliorates acute lung injury caused by avian influenza A H5N1 infection[J]. Science signaling, 2012, 5 (212): ra16.

4. Ju X, Yan Y, Liu Q, Li N, Sheng M, Zhang L, Li X, Liang Z, Huang F, Liu K,Zhao Y, Zhang Y, Zou Z, Du J, Zhong Y, Zhou H, Yang P, Lu H, Tian M, Li D, Zhang J, Jin N, Jiang C. Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome Rupture. J Virol. 2015 Oct;89(20):10347-58

5. LI XIAO, LIU YAN, WEN ZHONG-MEI, LI CHANG, LU HUI-JUN, TIAN MING-YAO, JIN KUO-SHI, SUN LI-LI, GAO PENG, YANG EN-CHENG, XU XIAO-HONG, KAN SHI-FU, WANG ZHUO-YUE, WANG YU-HANG, JIN NING-YI. Potent anti-tumor effects of a dual specific oncolytic adenovirus expressing apoptin in vitro and in vivo. Molecular cancer. 2010, 9: 10.

6. Zhang Y, Tang J, Yang N, Liu Q, Zhang Q, Zhang Y, Li N, Zhao Y, Li S, Liu S, Zhou H, Li X, Tian M, Deng J, Xie P, Sun Y, Lu H, Zhang MQ, Jin N, Jiang C. FAT10 Is Critical in Influenza A Virus Replication by Inhibiting Type I IFN. J Immunol. 2016 Aug 1;197(3):824-33.

7. LI XIAO, JIN NING-YI, MI ZHI-QIANG, LIAN HAI, SUN LI-LI, LI XUE-MEI, ZHENG HONG-LING. Antitumor effects of a recombinant fowlpox virus expressing Apoptin in vivo and in vitro. International journal of cancer. 2006, 119 (12): 2948-2957.

8. LIAN HAI, JIN NING-YI, LI XIAO, MI ZHI-QIANG, ZHANG JING-MIN, SUN LI-LI, LI XUE-MEI, ZHENG HONG-LING, LI PING. Induction of an effective anti-tumor immune response and tumor regression by combined administration of IL-18 and Apoptin. Cancer immunology immunotherapy. 2007, 56 (2): 181-192.

9. QI YAN-XIN, GUO HUAN-HUAN, HU NING-NING, HE DONG-YUN, ZHANG SHI, CHU YUN-JIE, HUANG YU-BIN, LI XIAO, SUN LI-LI, JIN NING-YI. Preclinical pharmacology and toxicology study of Ad-hTERT-E1a-Apoptin, a novel dual cancer-specific oncolytic adenovirus. Toxicology and applied pharmacology. 2014 Oct 15;280(2):362-9.

10. KAN SHI-FU, WANG YU-HANG, SUN LI-LI, JIA PENG, QI YAN-XIN, SU JIA-QIANG, LIU LEI, YANG GUO-HUA, LIU LI-MING, WANG ZHUO-YUE, WANG JIN-HUI, LIU GUANG-CHEN, JIN NING-YI, LI XIAO, DING ZHUANG. Attenuation of vaccinia Tian Tan strain by removal of viral TC7L-TK2L and TA35R genes. PloS one. 2012, 7 (2): e31979.

11. MA MING-XIAO, JIN NING-YI, WANG ZHEN-GUO, WANG RUI-LIN, FEI DONG-LIANG, ZHENG MING, YIN GE-FEN, LI CHANG, JIA LIE-LI, JIN KUO-SHI, ZHANG YING-JIU. Construction and immunogenicity of recombinant fowlpox vaccines coexpressing HA of AIV H5N1 and chicken IL18. Vaccine. 2006, 24 (20): 4304-4311.

12. SHEN GUO-SHUN, JIN NING-YI, MA MING-XIAO, JIN KUO-SHI, ZHENG MING, ZHUANG TIAN-ZHONG, LU HUI-JUN, ZHU GUANG-ZE, JIN HONG-TAO, JIN MING-LAN, HUO XIAO-WEI, QIN XIAO-BING, YIN RONG-LAN, LI CHANG, LI HONG-WEN, LI YANG, HAN ZHEN-ZHEN, CHEN YI-FENG, JIN MIAO-MIAO. Immune responses of pigs inoculated with a recombinant fowlpox virus coexpressing GP5/GP3 of porcine reproductive and respiratory syndrome virus and swine IL-18. Vaccine. 2007, 25 (21): 4193-4202.

13. MA MING-XIAO, JIN NING-YI, LIU HUI-JUAN, ZHENG MING, SHEN GUO-SHUN, ZHU GUANG-ZE, LU HUI-JUN, HUO XIAO-WEI, JIN MING-LAN, LI XU, MA HAI-LI, JI YUE, YIN GE-FEN, JIN KUO-SHI. Immunogenicity of plasmids encoding P12A and 3C of FMDV and swine IL-18. Antiviral research. 2007, 76 (1): 59-67.

14. WANG YU-HANG, KAN SHI-FU, DU SOU-WEN, QI YAN-XIN, WANG JIN-HUI, LIU LEI, JI HUI-FAN, HE DONG-YUN, WU NA, LI CHANG, CHI BAO-RONG, LI XIAO, JIN NING-YI. Characterization of an attenuated TE3L-deficient vaccinia virus Tian Tan strain. Antiviral research. 2012, 96 (3): 324-332.

15. HE DONG-YUN, SUN LI-LI, LI CHANG, HU NING-NING, SHENG YUAN, CHEN ZHI-FEI, LI XIAO, CHI BAO-RONG, JIN NING-YI. Anti-tumor effects of an oncolytic adenovirus expressing hemagglutinin-neuraminidase of Newcastle disease virus in vitro and in vivo. Viruses. 2014, 6(2): 856-874

16. ZHENG MIN, JIN NING-YI, LIU QI, HUO XIAO-WEI, LI YANG, HU BO, MA HAI-LI, ZHU ZHAN-BO, CONG YAN-ZHAO, LI XIAO, JIN MING-LAN, ZHU GUANG-ZE. Immunogenicity and protective efficacy of Semliki forest virus replicon-based DNA vaccines encoding goatpox virus structural proteins[J]. Virology. 2009, 391 (1): 33-43.

17. WANG HONG-WEI, COLE D, JIANG WEN-ZHENG, JIN HONG-TAO, FU NAN, CHEN ZHE, JIN NING-YI. Engineering and functional evaluation of a single-chain antibody against HIV-1 external glycoprotein gp120. Clinical and experimental immunology. 2005, 141 (1): 72-80.

18. LI CHANG, SHEN ZHEN-WEI, LI XIAO, BAI JIE-YING, ZENG LIN, TIAN MING-YAO, SONG YING-JIN, YE MING, DU SHOU-WEN, REN DA-YONG, LIU CUN-XIA, ZHU NA, SUN DAN-DAN, LI YI, JIN NING-YI. Protection against SHIV-KB9 infection by combining rDNA and rFPV vaccines based on HIV multiepitope and p24 protein in Chinese rhesus macaques. Clinical & developmental immunology. 2012, 2012: 958404.

19. ZHU GUANG-ZE, QU YONG-GANG, JIN NING-YI, SUN ZHONG-FENG, LIU TIE-MEI, LEE H, TIAN MING-YAO, WANG TIE-FENG. Seroepidemiology and molecular characterization of hepatitis E virus in Jilin, China. Infection. 2008, 36 (2): 140-146.

20. DU SHOU-WEN, LIU CUN-XIA, ZHU YI-LONG, WANG YU-HANG, REN DA-YONG, WANG MAO-PENG, TAN PENG, LI XIAO, TIAN MING-YAO, ZHANG YAN-FANG, LI JIN-ZE, ZHAO FEI, LI CHANG, JIN NING-YI. Construction and characterization of novel fowlpox virus shuttle vectors. Virus research. 2014, 197C: 59-66.

21. REN DA-YONG, LI CHANG, QIN YAN-QING, YIN RONG-LAN, DU SHOU-WEN, YE FEI, LIU HONG-FENG, WANG MAO-PENG, SUN YANG, LI XIAO, TIAN MING-YAO, JIN NING-YI. Lactobacilli Reduce Chemokine IL-8 Production in Response to TNF-a and Salmonella Challenge of Caco-2 Cells. BioMed research international. 2013, 2013: 925219.

22. LIU HAO, LIU ZHEN-JIANG, JING JIE, REN JING-QIANG, LIU YAN-YU, GUO HUAN-HUAN, FAN MIN, LU HUI-JUN, JIN NING-YI. Reverse Transcription Loop-Mediated Isothermal Amplification for Rapid Detection of Japanese Encephalitis Virus in Swine and Mosquitoes. Vector-borne and zoonotic diseases. 2012 ,12(12):1042-1052.

23. Liu HAO, Lu HUI-JUN, LIU ZHEN-JIANG, Jing JIE, Ren JING-QIANG, Liu YAN-YU, Lu FEI, Jin NING-YI. Japanese Encephalitis Virus in Mosquitoes and Swine in Yunnan Province, China 2009–2010. Vector-borne and zoonotic diseases. 2013,13(1):41-49

24. REN DA-YONG, LI CHANG, QIN YAN-QING, YIN RONG-LAN, DU SHOU-WEN, YE FEI, LIU CUN-XIA, LIU HUI, WANG MAO-PENG, LI YI, Sun Y, LI XIAO, TIAN MING-YAO, JIN NING-YI. In vitro evaluation of the probiotic and functional potential of Lactobacillus strains isolated from fermented food and human intestine. Anaerobe. 2014, 30: 1-10.

25. REN DA-YONG, LI CHANG, QIN YAN-QING, YIN RONG-LAN, LI XIAO, TIAN MING-YAO, DU SOU-WEN, GUO HUAN-HUAN, LIU CUN-XIA, ZHU NA, SUN DAN-DAN, LI YI, JIN NING-YI. Inhibition of Staphylococcus aureus adherence to Caco-2 cells by lactobacilli and other factors that influence attachment, Anaerobe. 2012, 18(5):508-515.)

26. KAN SHI-FU, JIA PENG, SUN LI-LI, HU NING-NING, LI CHANG, LU HUI-JUN, TIAN MING-YAO, QI YAN-XIN, JIN NING-YI, LI XIAO. Generation of an attenuated Tiantan vaccinia virus by deletion of the ribonucleotide reductase large subunit. Archives of virology. 2014, 159(9): 2223-2231.

27. JIN NING-YI, FUNAHASHI S, SHIDA H. Constructions of vaccinia virus A-type inclusion body protein, tandemly repeated mutant 7.5 kDa protein, and hemagglutinin gene promoters support high levels of expression. Archives of virology. 1994, 138 (3-4): 315-330.

28. ZHANG MU-CHUN, WANG JIN-HUI, LI CHANG, HU NING-NING, WANG KAI, JI HUI-FAN, HE DONG-YUN, QUAN CHENG-SHI, LI XIAO, JIN NING-YI, LI YU-LIN. Potent growth-inhibitory effect of a dual cancer-specific oncolytic adenovirus expressing apoptin on prostate carcinoma. International journal of oncology. 2013, 42 (3): 1052-1060.

29. TAN LEI, LU HUI-JUN, ZHANG DAN, TIAN MING-YAO, HU BO, WANG ZHUO-YUE, JIN NING-YI. Protection against H1N1 influenza challenge by a DNA vaccine expressing H3/H1 subtype hemagglutinin combined with MHC class II-restricted epitopes. Virology journal. 2010, 7: 363.

30. REN JING-QIANG, LU HUI-JUN, WEN SHU-BO, SUN WEN-CHAO, YAN FU-LONG, CHEN XIN, JING JIE, LIU HUI, LIU CUN-XIA, XUE FEI, XIAO PENG-PENG, XIN SHU, JIN NING-YI. Enhanced immune responses in pigs by DNA vaccine coexpressing GP3 and GP5 of European type porcine reproductive and respiratory syndrome virus. Journal of virological methods. 2014, 206: 27-37.

31. JIANG WEN-ZHENG, JIN NING-YI, LI ZI-JIAN, ZHANG LI-SHU, WANG HONG, ZHANG YING-JIU, HAN WEN-YU. Expression and characterization of Gag protein of HIV-1(CN) in Pichia pastoris. Journal of virological methods. 2005, 123 (1): 35-40.

32. ZHENG MIN, JIN NING-YI, ZHANG HONG-YONG, JIN MING-LAN, LU HUI-JUN, MA MAI-LI, LI CHANG, YIN GE-FEN, WANG RI-LIN, LIU QI. Construction and immunogenicity of a recombinant fowlpox virus containing the capsid and 3C protease coding regions of foot-and-mouth disease virus. Journal of virological methods. 2006, 136 (1-2): 230-237.

发明专利：

1. 金宁一等，专利名称：一种双特异抗肿瘤重组腺病毒及其构建模式和应用，专利号：ZL200910082428.4，授权日期：2012-1-12

2. 金宁一等，一种HIV复合多表位治疗性DNA疫苗及其应用，专利号：ZL200910087591.X，授权日期：2011-6-29

3. 金宁一等，抗HIV重组导向毒素，专利号：ZL 200310110098.8，授权日期：2008-10-8

4. 金宁一等，抗HIV-1外膜蛋白单链抗体及重组免疫毒素，专利号：ZL 01120240.8，授权日期：2004-11-24

5. 金宁一等，新城疫病毒HN和鸡贫血病毒VP3基因联合抗肿瘤生物制剂，专利号：ZL 01120236.X，授权日期：2004-7-7

6. 金宁一等，H5亚型高致病性禽流感病毒血凝素基因抗原蛋白的表达制备，专利号：ZL200510017149.1，授权日期：2011-8-10

7. 金宁一等，用于检测A型流感病毒的基因芯片、其制备方法及应用，专利号：ZL200910250409.8，授权日期：2012-6-13

8. 金宁一等，专利名称：一种鸡痘病毒载体穿梭质粒及其应用，专利号：ZL200910076152.9，授权日期：2011-8-19

9. 金宁一等，共表达猪圆环病毒及口蹄疫病毒的二联重组活载体疫苗，专利号：ZL200410011047.4，授权日期：2010-12-8

10. 金宁一等，一种痘苗病毒穿梭载体及其应用，专利号：ZL201110078138.X，授权日期：2013-3-13

11. 金宁一等，一种Asia I型FMDV复合多表位，专利号：ZL201010180733.X，授权日期：2012-11-7